Literal translations:
* What are we going to do with you? (This is a bit blunt and could be interpreted negatively, depending on tone)
* What shall we do with you? (Slightly more formal and less negative)
More nuanced translations:
* What are we going to do about you? (This implies a problem or situation involving the person)
* What are our plans with you? (This implies a more positive or collaborative situation)
* What are we going to do together? (This implies a shared activity or task)
It's important to consider the tone and context of the original Spanish phrase to choose the best translation.