Here are a few ways to express it:
* Two hundred fifty million (This is the most common and straightforward way)
* Two hundred and fifty million (This is also acceptable, but less common in American English)
* 250 million (This is often used in writing and informal speech)
* Two hundred fifty thousand thousand (This is technically correct, but not very practical)
It's important to note that there's no single "right" answer, and the best way to express the number will depend on the context.