* Un-: This is the most common and straightforward option, meaning "not." So, "unbreakable" or "unyielding" could be used to describe something that is indestructible.
* In-: This prefix also means "not" and can be used to create words like "invincible" or "impervious."
* Im-: Similar to "in-," this prefix also means "not" and can create words like "impenetrable" or "immortal," both of which imply a degree of indestructibility.
* A-: This prefix means "without" or "not" and can be used to create words like "aseismic" (resistant to earthquakes) or "asunder" (incapable of being broken apart), which can imply indestructibility in specific contexts.
Ultimately, the best prefix to use will depend on the specific meaning you want to convey.