Examples:
* Correct: Nowadays, people are more connected than ever before.
* Correct: Nowadays people are more connected than ever before.
However, if "nowadays" is used in a different context, it might require a comma. For example:
* Correct: We are living in a very different world nowadays, compared to just a few decades ago.
In this case, "nowadays" acts as a parenthetical phrase and is set off with commas.
Ultimately, the use of a comma depends on the specific sentence structure and meaning.