General synonyms:
* Significant: This emphasizes the importance or weight of something.
* Important: This focuses on the value or relevance of something.
* Purposeful: This highlights a clear reason or objective behind something.
* Substantial: This emphasizes the depth or richness of meaning.
* Impactful: This focuses on the effect or influence of something.
More specific synonyms:
* Insightful: This emphasizes the ability to understand and explain something deeply.
* Thought-provoking: This focuses on the ability to stimulate reflection or new ideas.
* Poignant: This emphasizes the emotional impact of something.
* Moving: This focuses on the ability to evoke strong emotions.
* Inspirational: This highlights the ability to motivate or encourage someone.
The best synonym will depend on the specific meaning you want to convey. For example, if you're talking about a meaningful relationship, "deep" or "intimate" might be better choices than "significant" or "important."