Direct opposites:
* Attack
* Assault
* Criticize
* Condemn
More nuanced opposites:
* Abandon
* Betray
* Surrender
* Compromise
* Neglect
* Yield
The best antonym will depend on the specific situation. For example, "attack" is a direct opposite if you're talking about physical defense, while "abandon" might be more appropriate if you're talking about defending someone's honor.