General Antonyms:
* In-: Incapable (lacking the ability or skill)
* Un-: Uncapable (less common, but sometimes used)
* Im-: Incompetent (lacking the necessary skills or qualities)
* Dis-: Disable (to make incapable)
Other Options:
* Ineffective: Not producing the desired results.
* Inefficient: Not using resources well.
* Unskilled: Lacking the necessary training or expertise.
* Powerless: Lacking the strength or authority.
The best prefix or antonym to use will depend on the specific situation and the meaning you want to express.