If "mere" means insignificant or unimportant:
* Significant
* Important
* Major
* Substantial
* Meaningful
If "mere" means only or nothing more than:
* More than
* Beyond
* In addition to
* Not just
If "mere" is used to emphasize something small or simple:
* Complex
* Elaborate
* Extensive
* Grand
Example:
* Original sentence: The painting is a mere copy.
* Antonym sentence: The painting is a masterpiece.
The best antonym will depend on the specific context of the sentence.