Formal:
* Êtes-vous fatigué(e) ? (Are you tired?) - This is the most formal way to ask. You use "vous" for the formal "you."
Informal:
* Tu es fatigué(e) ? (Are you tired?) - This is the informal way to ask, using "tu" for the informal "you."
* T'es fatigué(e) ? (Are you tired?) - This is even more informal, using a shortened form of "tu es."
Other options:
* Vous avez l'air fatigué(e). (You look tired.)
* Vous semblez fatigué(e). (You seem tired.)
Important note:
* If you're speaking to a group of people, you would use the plural form of "fatigué(e)": Êtes-vous fatigués(es) ? (Are you tired?)
Choose the option that best suits the situation and your relationship with the person you're speaking to.