* If blithe means carefree and lighthearted, its opposite could be:
* Serious
* Solemn
* Grave
* Worried
* Anxious
* Gloomy
* If blithe means indifferent or unconcerned, its opposite could be:
* Concerned
* Attentive
* Careful
* Thoughtful
* Serious
* If blithe means cheerful and happy, its opposite could be:
* Sad
* Unhappy
* Depressed
* Melancholy
The most appropriate opposite will depend on the context in which you are using the word "blithe."