For creation as the act of making something:
* Destruction: This is the most direct opposite of creating something.
* Annihilation: This implies complete destruction.
* Demolition: This focuses on the physical act of tearing something down.
* Erasure: This refers to the act of removing something completely.
For creation as a thing that is made:
* Destruction: This is still relevant, as it implies the opposite of something existing.
* Nonexistence: This is a broader term that means the absence of something.
* Nothingness: This is a philosophical term for the state of being without anything.
For creation as the process of forming the universe:
* Annihilation: This could be used to describe the ultimate end of the universe.
* The Big Crunch: This is a theoretical event where the universe collapses in on itself.
For creation as a work of art:
* Destruction: This can refer to the physical destruction of the art piece.
* Negation: This can refer to the artist's intention to negate or undo the creation process.
* Degradation: This can refer to the deterioration or decay of the art piece over time.
The best antonym for "creation" will depend on the specific context in which you are using the word.