* "A" opportunity: This refers to a general, unspecified opportunity. Example: "I'm looking for a new opportunity to learn."
* "The" opportunity: This refers to a specific opportunity that has already been mentioned or is understood in context. Example: "I applied for the opportunity to lead the project."
However, you wouldn't use an article if you're talking about the concept of opportunity in general.
For example:
* "Opportunity is knocking." (No article needed)
So, it depends on the context and whether you're referring to a specific opportunity or the general concept of opportunity.