1. Specify which 21 countries you're interested in: There are many Spanish-speaking countries. Are you interested in all of them, or do you have a particular group in mind (e.g., Latin America, Europe, etc.)?
2. Clarify what you mean by "regions": Do you want to know about:
* Administrative regions: Like states, provinces, departments, etc.
* Geographic regions: Like the Andes Mountains, the Amazon rainforest, etc.
* Cultural regions: Like different dialects of Spanish, traditional music styles, etc.
Once you clarify these points, I can give you a much more helpful and focused answer!
