1. As a complete sentence:
* "Know what I mean?" (This is a question, so it ends with a question mark.)
2. As a phrase within a sentence:
* "I'm really tired, you know what I mean?" (The phrase is part of the larger sentence, so it uses a comma.)
* "I'm really tired—you know what I mean?" (The em dash adds emphasis and separates the phrase.)
* "I'm really tired; you know what I mean." (The semicolon is used to connect two closely related independent clauses.)
3. As an interjection:
* "I'm really tired. You know what I mean!" (The exclamation mark emphasizes the sentence.)
Ultimately, the best punctuation choice depends on the specific situation and the tone you want to convey.