* Formal: Ella (she)
* Informal: Ella (she)
In Spanish, you don't use a different pronoun for "your" grandmother like you might in English ("she" vs. "my grandmother"). The informal "ella" is used for both close and distant relatives.
For example:
* Formal: Ella es mi abuela. (She is my grandmother)
* Informal: Ella me quiere mucho. (She loves me a lot.)